Central in Bwiti religion

Brew from Banisteriopsis caapi and DMT-containing plants

Potent and dangerous; used in many cultures for its psychoactive effects

Natural psychedelic from cacti; long history of indigenous use.

Contains mescaline

Used by Mazatec shamans

Known for its potent and dangerous psychoactive properties

Found in toads and some plants.

Historically used in rituals and as medicine

Source of opium and various opiates

Source of opium, used historically for pain relief and recreation

Used in various cultures

Similar to Peyote

Used by indigenous cultures

Distinctive red and white mushroom

Used historically in magic and witchcraft

Cannabis-infused beverage traditionally used in Hindu festivals and rituals

Often used in Ayahuasca, but also alone

Contains THC and CBD; used both recreationally and medicinally

Commonly combined with Caapi Vine in Ayahuasca

Seeds contain LSA, a naturally occurring psychedelic

Known for its calming effects; used in social and ceremonial settings

Seeds of certain plants like Morning Glory.

Used in traditional ceremonies. Seeds contain LSA, a compound similar to LSD.

Used as an MAOI and in traditional healing

Seeds and bark used for their psychoactive properties

Used in ancient Egypt

Traditional use for energy and as a mild stimulant

Traditional Chinese medicine use for respiratory issues and as a stimulant

Used as a mood enhancer

Leaves chewed for mild stimulant effect

Leaves used for pain, anxiety, and opioid withdrawal

One of the oldest known alcoholic drinks, often used in ancient rituals

Seeds contain LSA

Seeds contain LSA, similar to Hawaiian Baby Woodrose

Tobacco-based snuff

Traditional Japanese alcoholic drink, used in various ceremonies and socially

Used for its distinct flavor and medicinal properties

Used for its auditory hallucinations and yellow vision

Key ingredient in absinthe, traditional use in medicine

Used in Ayurveda for stress relief and vitality

Used in various cultural contexts. Often chewed in combination with betel leaf and lime

Used in traditional medicine, particularly in Chinese and Ayurvedic practices

Used in Mayan and Aztec ceremonies

Traditional use in Ayurveda, Native American medicine, and as a stimulant

Used for its medicinal properties

Traditional fermented beverage, often maize-based, used in various rituals

Widely consumed globally for its stimulating effects

Historically used for its relaxing and aphrodisiac effects

Seeds used for their high caffeine content

Frog secretion used for cleansing

Used in various Asian traditional medicines and spiritual practices

Stronger variety of tobacco used in Amazonian shamanism

Used in traditional medicine and divination

In large doses, has psychoactive effects; commonly used as a spice

Used for its calming and sleep-inducing properties

Traditional Mexican alcoholic beverage made from fermented agave sap

Used in traditional medicine and cooking

Used for its mood-elevating and medicinal properties

Used for ocular health and spiritual insight

Used for its calming and sedative effects

Widely used in both social and ritual contexts

Used for its sedative and anxiolytic effects

Known for mild effects

Popular in South America, known for its energizing effects, stimulating and nutritional properties.

Used in Ayurveda for cognitive enhancement

Used for memory enhancement and circulatory benefits

Used in Ayurveda and traditional Chinese medicine for cognitive benefits

Used in brewing beer and for its calming effects

Widely used for relaxation and in aromatherapy

Used for its calming effects and pleasant flavor

Known for its nutritional benefits and as an adaptogen

Used for its adaptogenic and energizing properties