Dissociative

Unlike serotonergic psychedelics, dissociatives primarily act on NMDA glutamate receptors. Common examples include ketamine, PCP, and DXM. Effects often include altered body perception, analgesia, and at higher doses, experiences described as "k-holes" or out-of-body states. Ketamine has gained particular clinical attention for its rapid antidepressant effects and is now used in supervised therapeutic settings.