Chemistry
Ibogaine
The primary psychoactive alkaloid found in the root bark of the Tabernanthe iboga shrub, studied for its potential to interrupt opioid addiction.
Native to Central West Africa, iboga has been used in Bwiti spiritual traditions for centuries. Ibogaine has drawn significant clinical interest for its reported ability to interrupt opioid addiction and reduce withdrawal symptoms. Its mechanism of action is complex, involving multiple receptor systems including NMDA, opioid, and serotonin receptors. It carries cardiac risks (particularly QT prolongation) and requires medical supervision. Treatment typically involves a single extended session lasting 24-36 hours.