Reference tool
Substance Interaction Checker
Pick two substances to see what's known about combining them. Covers psychedelic medicines, prescribed psychiatric medications, and common recreational substances. Built from TripSit, MAPS clinical guidance, PsychonautWiki, and standard pharmacological references.
This is reference material, not medical advice. Same combination can be safe in one context and dangerous in another -- dose, timing, individual physiology, and concurrent conditions all matter. Always verify with a qualified healthcare provider before combining anything.
Important: Never stop prescribed medication without supervision. Discontinuing antidepressants, mood stabilizers, or anxiety medications abruptly can be more dangerous than the original interaction would have been.
Absence of an entry doesn't mean a combination is safe. Treat undocumented pairings conservatively.
Common questions
27 substances · 73 catalogued interactions · Most-asked combinations above; or pick any two from the dropdowns.
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