Directory
Deep research and collection of natural psychoactive medicines.
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Iboga
Strength
Type of Effect
Hallucinogenic
Duration of Effect
24-48 hours
Method of Use
Oral
Traditional Uses
Spiritual, Addiction
First Known Use
Ancient
Origin
Central West Africa
Ayahuasca
Strength
Type of Effect
Hallucinogenic
Duration of Effect
4-8 hours
Method of Use
Oral (Brew)
Traditional Uses
Spiritual, Healing
First Known Use
Ancient
Origin
Amazon Basin
Datura
Strength
Datura stramonium
Type of Effect
Hallucinogenic, Deliriant
Duration of Effect
Variable
Method of Use
Oral, Smoking
Traditional Uses
Shamanic, Medicinal
First Known Use
Ancient
Origin
Global
Mescaline
Strength
Peyote, San Pedro
Type of Effect
Hallucinogenic, Colorful Visuals
Duration of Effect
10-12 hours
Method of Use
Oral
Traditional Uses
N/A
First Known Use
Ancient
Origin
Americas (Peyote cactus, San Pedro cactus)
Peyote
Strength
Type of Effect
Hallucinogenic
Duration of Effect
8-12 hours
Method of Use
Oral
Traditional Uses
Spiritual, Healing
First Known Use
Ancient
Origin
North America
Salvia Divinorum
Strength
Type of Effect
Dissociative
Duration of Effect
5-30 minutes
Method of Use
Smoking, Chewing
Traditional Uses
Spiritual, Divination
First Known Use
Ancient
Origin
Mexico
Belladonna
Strength
Atropa belladonna
Type of Effect
Hallucinogenic, Deliriant
Duration of Effect
Variable
Method of Use
Oral, Topical
Traditional Uses
Medicinal, Magical
First Known Use
Ancient
Origin
Europe, North Africa, Western Asia
Bufotenin
Strength
Type of Effect
Hallucinogenic, Intense
Duration of Effect
15-45 mins
Method of Use
Smoking, Snorting
Traditional Uses
Shamanic Use
First Known Use
Ancient
Origin
South America
Mandrake
Strength
Mandragora officinarum
Type of Effect
Hallucinogenic
Duration of Effect
Variable
Method of Use
Oral
Traditional Uses
Magical, Medicinal
First Known Use
Ancient
Origin
Mediterranean, Himalayas
Opium Poppy
Strength
Papaver somniferum
Type of Effect
Analgesic, Sedative
Duration of Effect
Variable
Method of Use
Oral, Smoking
Traditional Uses
Medicinal, Recreational
First Known Use
Ancient
Origin
Eastern Mediterranean
Poppy
Strength
Papaver somniferum
Type of Effect
Sedative, Analgesic
Duration of Effect
Variable
Method of Use
Oral, Smoking
Traditional Uses
Medicinal, Recreational
First Known Use
Ancient
Origin
Eastern Mediterranean
Psilocybin Mushrooms
Strength
Type of Effect
Hallucinogenic
Duration of Effect
4-6 hours
Method of Use
Oral
Traditional Uses
Spiritual, Healing
First Known Use
Ancient
Origin
Global
San Pedro
Strength
San Pedro Cactus
Type of Effect
Hallucinogenic
Duration of Effect
8-12 hours
Method of Use
Oral
Traditional Uses
Healing, Spiritual
First Known Use
Ancient
Origin
South America
Yopo
Strength
Type of Effect
Hallucinogenic
Duration of Effect
15-60 minutes
Method of Use
Nasal (Snuff)
Traditional Uses
Shamanic, Spiritual
First Known Use
Ancient
Origin
South America
Amanita Muscaria
Strength
Type of Effect
Hallucinogenic
Duration of Effect
6-8 hours
Method of Use
Oral
Traditional Uses
Shamanic, Spiritual
First Known Use
Ancient
Origin
Northern Hemisphere
Henbane
Strength
Hyoscyamus niger
Type of Effect
Hallucinogenic
Duration of Effect
Variable
Method of Use
Oral, Smoking
Traditional Uses
Shamanic, Healing
First Known Use
Ancient
Origin
Europe, North Africa
Bhang
Strength
Type of Effect
Euphoric, Hallucinogenic
Duration of Effect
2-4 hours
Method of Use
Oral (Beverage)
Traditional Uses
Religious, Medicinal
First Known Use
Ancient
Origin
India
Caapi Vine
Strength
Banisteriopsis caapi
Type of Effect
Hallucinogenic
Duration of Effect
4-6 hours
Method of Use
Oral (Brew)
Traditional Uses
Spiritual, Healing
First Known Use
Ancient
Origin
Amazon Basin
Cannabis
Strength
Marijuana
Type of Effect
Relaxing, Euphoric
Duration of Effect
2-6 hours
Method of Use
Smoking, Oral
Traditional Uses
Medicinal, Recreational, Pain, Anxiety, Epilepsy
First Known Use
Ancient
Origin
Central Asia
Chacruna
Strength
Psychotria viridis
Type of Effect
Hallucinogenic
Duration of Effect
4-6 hours
Method of Use
Oral (Brew)
Traditional Uses
Spiritual, Healing
First Known Use
Ancient
Origin
Amazon Basin
Hawaiian Baby Woodrose
Strength
Argyreia nervosa
Type of Effect
Psychedelic
Duration of Effect
6-8 hours
Method of Use
Oral (Seeds)
Traditional Uses
Shamanic
First Known Use
Unknown
Origin
Indian Subcontinent
Kava Kava
Strength
Piper methysticum
Type of Effect
Relaxant, Euphoric
Duration of Effect
2-3 hours
Method of Use
Oral (Beverage)
Traditional Uses
Medicinal, Social
First Known Use
Ancient
Origin
South Pacific
Morning Glory
Strength
Type of Effect
Sedative, Dreamy
Duration of Effect
6-10 hours
Method of Use
Oral
Traditional Uses
N/A
First Known Use
Ancient
Origin
Central America
Ololiuqui
Strength
Turbina corymbosa
Type of Effect
Psychedelic
Duration of Effect
6-10 hours
Method of Use
Oral (Seeds)
Traditional Uses
Divination, Healing
First Known Use
Ancient, Pre-Columbian
Origin
Mexico
Syrian Rue
Strength
Peganum harmala
Type of Effect
Hallucinogenic
Duration of Effect
2-6 hours
Method of Use
Oral, Smoking
Traditional Uses
Shamanic, Healing
First Known Use
Ancient
Origin
Middle East
Voacanga africana
Strength
Type of Effect
Stimulant, Hallucinogenic
Duration of Effect
Variable
Method of Use
Oral
Traditional Uses
Medicinal, Ritualistic
First Known Use
Unknown
Origin
West Africa
Blue Lotus
Strength
Type of Effect
Sedative
Duration of Effect
2-4 hours
Method of Use
Smoking, Oral (Tea)
Traditional Uses
Ceremonial, Recreational
First Known Use
Ancient
Origin
Ancient Egypt
Coca Leaves
Strength
Erythroxylum coca
Type of Effect
Stimulant
Duration of Effect
1-2 hours
Method of Use
Chewing
Traditional Uses
Medicinal, Ritualistic
First Known Use
Pre-Columbian
Origin
South America
Ephedra
Strength
Ephedra sinica
Type of Effect
Stimulant
Duration of Effect
2-4 hours
Method of Use
Oral
Traditional Uses
Medicinal, Energizing
First Known Use
Ancient
Origin
China
Kanna
Strength
Type of Effect
Mood Elevating
Duration of Effect
1-2 hours
Method of Use
Chewing, Smoking
Traditional Uses
Stress, Appetite Loss
First Known Use
Ancient
Origin
South Africa
Khat
Strength
Catha edulis
Type of Effect
Stimulant
Duration of Effect
3-4 hours
Method of Use
Chewing
Traditional Uses
Social, Recreational
First Known Use
Ancient
Origin
Horn of Africa, Arabian Peninsula
Kratom
Strength
Mitragyna speciosa
Type of Effect
Stimulant/Sedative
Duration of Effect
2-6 hours
Method of Use
Oral
Traditional Uses
Pain Relief, Opiate Withdrawal
First Known Use
Ancient
Origin
Southeast Asia
Mead
Strength
Type of Effect
Relaxant, Euphoric
Duration of Effect
Variable
Method of Use
Oral (Beverage)
Traditional Uses
Ceremonial, Recreational
First Known Use
Ancient
Origin
Europe, Africa, Asia
Morning Glory
Strength
Type of Effect
Psychedelic
Duration of Effect
6-10 hours
Method of Use
Oral (Seeds)
Traditional Uses
Shamanic, Divination
First Known Use
Ancient
Origin
Central America
Ipomoea tricolor
Strength
Type of Effect
Psychedelic
Duration of Effect
6-10 hours
Method of Use
Oral (Seeds)
Traditional Uses
Shamanic, Divination
First Known Use
Ancient
Origin
Central America
Rapé
Strength
Type of Effect
Stimulating
Duration of Effect
1-2 hours
Method of Use
Nasal
Traditional Uses
Cleansing, Spiritual
First Known Use
Unknown
Origin
Amazon Basin
Sake
Strength
Rice Wine
Type of Effect
Relaxant, Cultural
Duration of Effect
Variable
Method of Use
Oral (Beverage)
Traditional Uses
Ceremonial, Social
First Known Use
3rd century
Origin
Japan
Sassafras
Strength
Type of Effect
Relaxant, Aromatic
Duration of Effect
Variable
Method of Use
Oral (Tea)
Traditional Uses
Medicinal, Culinary
First Known Use
Ancient
Origin
North America, East Asia
Sinicuichi
Strength
Heimia salicifolia
Type of Effect
Hallucinogenic
Duration of Effect
2-4 hours
Method of Use
Oral (Tea)
Traditional Uses
Ritualistic, Divinatory
First Known Use
Ancient
Origin
Americas
Wormwood
Strength
Artemisia absinthium
Type of Effect
Stimulant, Hallucinogenic
Duration of Effect
Variable
Method of Use
Oral
Traditional Uses
Medicinal, Recreational
First Known Use
Ancient
Origin
Europe, Asia, North Africa
Ashwagandha
Strength
Withania somnifera
Type of Effect
Adaptogenic, Anxiolytic
Duration of Effect
2-6 hours
Method of Use
Oral
Traditional Uses
Medicinal, Adaptogenic
First Known Use
Ancient
Origin
India, Middle East
Betel Nut
Strength
Areca catechu
Type of Effect
Stimulant
Duration of Effect
1-3 hours
Method of Use
Chewing
Traditional Uses
Social, Cultural
First Known Use
Ancient
Origin
Southeast Asia
Bitter Orange
Strength
Citrus aurantium
Type of Effect
Stimulant
Duration of Effect
1-2 hours
Method of Use
Oral
Traditional Uses
Digestive, Sedative
First Known Use
Ancient
Origin
Southeast Asia, Eastern Africa
Cacao
Strength
Type of Effect
Mood Boosting
Duration of Effect
2-3 hours
Method of Use
Oral
Traditional Uses
Ceremonial, Nutritional
First Known Use
Pre-Columbian
Origin
Central and South America
Calamus
Strength
Acorus calamus
Type of Effect
Stimulant, Hallucinogenic
Duration of Effect
2-4 hours
Method of Use
Oral
Traditional Uses
Medicinal, Cultural
First Known Use
Ancient
Origin
Asia, North America
Cat's Claw
Strength
Uncaria tomentosa
Type of Effect
Immunostimulant
Duration of Effect
Variable
Method of Use
Oral
Traditional Uses
Healing, Anti-inflammatory
First Known Use
Ancient
Origin
South America
Chicha
Strength
Type of Effect
Social, Ceremonial
Duration of Effect
Variable
Method of Use
Oral (Beverage)
Traditional Uses
Ceremonial, Social
First Known Use
Pre-Columbian
Origin
South America
Coffee
Strength
Type of Effect
Stimulant
Duration of Effect
2-4 hours
Method of Use
Oral (Beverage)
Traditional Uses
Social, Energizing
First Known Use
9th century
Origin
Ethiopia
Damiana
Strength
Turnera diffusa
Type of Effect
Relaxant
Duration of Effect
1-2 hours
Method of Use
Smoking, Oral
Traditional Uses
Aphrodisiac, Relaxant
First Known Use
Pre-Columbian
Origin
Central and South America, Caribbean
Guarana
Strength
Paullinia cupana
Type of Effect
Stimulant
Duration of Effect
2-6 hours
Method of Use
Oral
Traditional Uses
Medicinal, Energizing
First Known Use
Pre-Columbian
Origin
Amazon Basin
Kambo
Strength
Type of Effect
Purging, Intense
Duration of Effect
15-30 minutes
Method of Use
Topical (Skin)
Traditional Uses
Healing, Cleansing
First Known Use
Unknown
Origin
Amazon Basin
Lotus
Strength
Nelumbo nucifera
Type of Effect
Sedative, Spiritual
Duration of Effect
2-4 hours
Method of Use
Oral, Smoking
Traditional Uses
Medicinal, Ceremonial
First Known Use
Ancient
Origin
Asia
Mapacho
Strength
Nicotiana rustica
Type of Effect
Stimulant, Relaxant
Duration of Effect
1-2 hours
Method of Use
Smoking, Snuff
Traditional Uses
Ritualistic, Medicinal
First Known Use
Ancient
Origin
Amazon Basin
Mugwort
Strength
Artemisia vulgaris
Type of Effect
Dream-Potentiating
Duration of Effect
Variable
Method of Use
Smoking, Oral
Traditional Uses
Spiritual, Healing
First Known Use
Ancient
Origin
Eurasia, North America
Nutmeg
Strength
Myristica fragrans
Type of Effect
Hallucinogenic, Sedative
Duration of Effect
Up to 24 hours
Method of Use
Oral
Traditional Uses
Medicinal, Culinary
First Known Use
Ancient
Origin
Indonesia
Passionflower
Strength
Passiflora
Type of Effect
Sedative, Relaxant
Duration of Effect
2-3 hours
Method of Use
Oral (Tea)
Traditional Uses
Medicinal, Sleep Aid
First Known Use
Pre-Columbian
Origin
Americas
Pulque
Strength
Type of Effect
Relaxant, Social
Duration of Effect
Variable
Method of Use
Oral (Beverage)
Traditional Uses
Ceremonial, Social
First Known Use
Pre-Columbian
Origin
Mexico
Sage
Strength
Salvia officinalis
Type of Effect
Cognitive Enhancing
Duration of Effect
Variable
Method of Use
Oral, Smoking
Traditional Uses
Healing, Culinary
First Known Use
Ancient
Origin
Mediterranean
Saint John's Wort
Strength
Hypericum perforatum
Type of Effect
Mood Elevating
Duration of Effect
2-4 hours
Method of Use
Oral
Traditional Uses
Medicinal, Antidepressant
First Known Use
Ancient
Origin
Europe, Asia
Sananga
Strength
Type of Effect
Visionary, Healing
Duration of Effect
Minutes
Method of Use
Eye Drops
Traditional Uses
Healing, Spiritual
First Known Use
Unknown
Origin
Amazon Basin
Skullcap
Strength
Scutellaria
Type of Effect
Anxiolytic, Sedative
Duration of Effect
1-2 hours
Method of Use
Oral (Tea)
Traditional Uses
Medicinal, Relaxant
First Known Use
Ancient
Origin
North America, East Asia
Tobacco
Strength
Nicotiana tabacum
Type of Effect
Stimulant
Duration of Effect
Minutes
Method of Use
Smoking, Snuff
Traditional Uses
Social, Ceremonial
First Known Use
Pre-Columbian
Origin
Americas
Valerian
Strength
Valeriana officinalis
Type of Effect
Sedative, Anxiolytic
Duration of Effect
4-6 hours
Method of Use
Oral
Traditional Uses
Medicinal, Sleep Aid
First Known Use
Ancient
Origin
Europe, Asia
Wild Dagga
Strength
Type of Effect
Euphoric
Duration of Effect
1-2 hours
Method of Use
Smoking, Oral
Traditional Uses
Ceremonial, Recreational
First Known Use
Unknown
Origin
South Africa
Yerba Mate
Strength
Ilex paraguariensis
Type of Effect
Stimulant, Energizing
Duration of Effect
2-4 hours
Method of Use
Oral (Beverage)
Traditional Uses
Social, Energizing
First Known Use
Pre-Columbian
Origin
South America
Bacopa
Strength
Bacopa monnieri
Type of Effect
Cognitive Enhancing
Duration of Effect
2-4 hours
Method of Use
Oral
Traditional Uses
Medicinal, Nootropic
First Known Use
Ancient
Origin
India, Asia
Ginkgo
Strength
Ginkgo biloba
Type of Effect
Cognitive Enhancing
Duration of Effect
Variable
Method of Use
Oral
Traditional Uses
Medicinal, Nutritional
First Known Use
Ancient
Origin
China
Gotu Kola
Strength
Centella asiatica
Type of Effect
Cognitive Enhancing
Duration of Effect
2-4 hours
Method of Use
Oral
Traditional Uses
Medicinal, Nutritional
First Known Use
Ancient
Origin
Asia, South Pacific
Hops
Strength
Humulus lupulus
Type of Effect
Sedative, Relaxant
Duration of Effect
1-2 hours
Method of Use
Oral, Smoking
Traditional Uses
Medicinal, Brewing
First Known Use
Ancient
Origin
Europe, Western Asia
Lavender
Strength
Lavandula
Type of Effect
Relaxant, Anxiolytic
Duration of Effect
1-2 hours
Method of Use
Oral, Aromatherapy
Traditional Uses
Medicinal, Aromatic
First Known Use
Ancient
Origin
Mediterranean
Lemon Balm
Strength
Melissa officinalis
Type of Effect
Relaxant, Anxiolytic
Duration of Effect
1-2 hours
Method of Use
Oral (Tea)
Traditional Uses
Medicinal, Culinary
First Known Use
Ancient
Origin
Mediterranean, Europe
Maca
Strength
Lepidium meyenii
Type of Effect
Energizing, Nutritional
Duration of Effect
Variable
Method of Use
Oral
Traditional Uses
Nutritional, Medicinal
First Known Use
Pre-Columbian
Origin
South America
Rhodiola
Strength
Rhodiola rosea
Type of Effect
Adaptogenic, Energizing
Duration of Effect
2-4 hours
Method of Use
Oral
Traditional Uses
Medicinal, Adaptogenic
First Known Use
Ancient
Origin
Europe, Asia